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报告题目：Molecular imaging and disease diagnosis with renal-clearable optical agents
报告时间：2023-10-20 16:00
报告人： 黄佳国 教授
中山大学 药学院
报告地点：翔安校区能源材料大楼3号楼会议室5
转播地点：思明校区化学楼234会议室
报告摘要：
With signal amplification and multiplexing capability, optical nanoparticles have found their unique position in in-vitro diagnostics. However, their in vivo sensing applications are mainly limited to preclinical settings, because their large sizes often result in slow clearance from the body after systemic administration, raising long-term toxicity issues. Moreover, the issue of light scattering and tissue reabsorption makes them effective only for superficial imaging. To address these limitations, we develop activatable polymeric nanosensors (APNs) with biomarker-triggered nanoparticle-to-molecule pharmacokinetic conversion and near-infrared fluorogenic turn-on response. APNs can accumulate at the disease site and react with disease-associated proteases to undergo in-situ enzyme-catalyzed depolymerization. This disease-specific interaction liberates renal-clearable fluorogenic fragments from APNs for noninvasive longitudinal urinalysis and outperforms the gold standard blood and urine assays, providing a level of sensitivity and specificity comparable to invasive biopsy and flow cytometry analysis. In rodent models, APNs enable ultrasensitive detection of tumors (1.6 mm diameter) and early diagnosis of acute liver allograft rejection. We anticipate that our modular nanosensor platform may be applied for early diagnosis of a range of diseases via a simple urine test.
报告人简介：
黄佳国，中山大学药学院，教授，博士生导师，入选“国家海外青年人才计划项目”及欧盟玛丽居里学者。2016年于德国海德堡大学获得博士学位。2016年至2021年先后在德国海德堡大学及新加坡南洋理工大学从事博士后研究。2021年9月加入中山大学药学院。研究方向包括分子探针的开发及其在重大疾病中诊断，监测与治疗应用。近年来开发了可穿戴智能经皮光学检测设备及系列分子探针用于早期检测肾功能、药源性急性肾损伤、膀胱癌、肿瘤免疫治疗、缺血再灌注损伤、肝癌及急性肝移植排斥反应等多种重大疾病，并率先提出并建立了基于有机分子探针的尿液检测技术。迄今共发表SCI论文70余篇，申请发明专利10项。其中于第一及通讯作者身份发表论文20多篇，包括Nature Materials（2篇），Nature Reviews Chemistry（1篇），Angew Chem Int Ed（5篇），Adv Mater（1篇），Adv Func Mater （1篇），Chemical science（2篇）等，引用次数超6000次。
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