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报告题目： Bioinspired reactions enabled by porphyrinoids
报告时间：2023-10-17 09:00
报告人： Dorota Gryko 教授
Institute of Organic Chemistry Polish Academy of Sciences
报告地点：思明校区卢嘉锡202报告厅
转播地点：翔安校区能源材料大楼3号楼会议室5，漳州校区生化主楼307教室
报告摘要：
Porphyrinoids, also known as the pigments of life, are a class of naturally occurring organic dyes. They play key roles in crucial processes that support life - oxygen transport (hem), electron transport (cytochrome c), photosynthesis (chlorophyll a), and synthesis of DNA (vitamin B12). Following nature, we have been exploiting the potential of these compounds in catalysis. Vitamin B12 - catalysis has been successfully translated into the laboratory.1-2 The advantage of using vitamin B12 as a catalyst lays in the complete stability of the central cobalt ion and by the definition it is nontoxic. It has also been well documented that the reaction mechanism usually follows a radical pathway, bringing a new dimension to this already interesting field.2Along this line, we have developed new vitamin B12-catalyzed reactions involving reduction of Co(III) to Co(I) or Co(II) and subsequent reactions with electrophiles or radicals. Vitamin B12 derivative unusually catalyzes a new olefinic sp2 C-H alkylation reaction with diazo reagents as a carbene source, acylation of activated olefins, alkylation of strained molecules. 3-5 We have also proved that porphyrinoids are valuable photoredox catalysts that can be activated with both blue and red light. 6 These key findings emphasize the unique feature of porphyrinoids as catalysts to achieve something unachievable with other methodologies or to find a greener approach.
报告人简介：
Dorota Gryko is a professor in Institute of Organic Chemistry Polish Academy of Sciences. Her scientific interest including homogenous catalysis, photocatalysis, Co-catalysis, carbene chemistry, vitamin B12 chemistry and catalysis, vitamin B12 as a delivery vehicle. Her group recently discovered of a completely new reactivity of strained cyclobutanes by the use of nucleophilic properties of vitamin B12 derivatives. They also discovered that diazo compounds can be a source not only of carbenes but also of alkyl radicals, and proposed the use of thioamides-derivatives of α-amino acids as new organocatalysts in asymmetric synthesis. Dorota Gryko has received several awards and recognitions for her research, including Maria Curie Prize (UMCS Lublin) in 2019 for "The discovery of new biological properties of porphyrins in the fight of nosema”. Dorota Gryko has authored close to 130 scientific papers which have drawn over 2501 citations without self-citation.
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