Education and Research Experience: 

2008-2012: Bachelor, College of Chemistry, Liaoning University

2012-2017: PhD, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

2018-2022: Postdoctoral researcher, School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore

2022-Present: Professor, College of Chemistry and Chemical Engineering, Xiamen University

Principal Research Interests:

Biomedical Polymers; Nanomedicine; Immunotherapy; Molecular Probe design; Disease Detection and Monitoring

Selected Recent Publications:

1. 1. Shasha He, Penghui Cheng, Kanyi Pu*. Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine. Nature Biomedical Engineering, 2023, 7, 281–297.

2. 2. Shasha He^#, Jing Liu^#, Chi Zhang, Jun Wang* and Kanyi Pu*. Semiconducting Polymer Nano-regulators with Cascading Activation for Photodynamic Cancer Immunotherapy. Angewandte Chemie International Edition, 2022, 61, e202116669.

3. 3. Shasha He^#, Jingchao Li^#, Penghui Cheng, Ziling Zeng, Chi Zhang, Hongwei Duan, Kanyi Pu*. Charge-reversal polymer nano-modulators for photodynamic immunotherapy of cancer. Angewandte Chemie International Edition, 2021, 60, 19355-19363.

4. 4. Shasha He, Jingchao Li, Yan Lyu, Jiaguo Huang, Kanyi Pu*. Near-infrared fluorescent macromolecular reporters for real-time imaging and urinalysis of cancer immunotherapy. Journal of the American Chemical Society, 2020, 142, 7075-7082.

5. 5. Shasha He, Yanyu Jiang, Jingchao Li, Kanyi Pu*. Semiconducting polycomplex nanoparticles for photothermal ferrotherapy of cancer. Angewandte Chemie International Edition, 2020, 59, 10633-10638.

6. 6. Shasha He, Chen Xie, Yuyan Jiang, Kanyi Pu*. An organic afterglow protheranostic nanoassembly. Advanced Materials, 2019, 31, 1902672.

7. 7. Shasha He, Chan Li, Qingfei Zhang, Jianxun Ding, Xing-Jie Liang, Xuesi Chen, Haihua Xiao*, Xiaoyuan Chen*, Dongfang Zhou*, and Yubin Huang. Tailoring platinum(IV) amphiphiles for self-targeting all-in-one assemblies as precise multimodal theranostic nanomedicine. ACS Nano, 2018, 12, 7272-7281.

8. 8. Shasha He, Yanxin Qi, Gaizhen kuang, Dongfang Zhou*, Jizhen Li, Zhigang Xie, Xuesi Chen, Xiabin Jing, Yubin Huang*. Single-stimulus dual-drug sensitive nanoplatform for enhanced photoactivated therapy. Biomacromolecules, 2016, 17, 2120-2127.

9. 9. Shasha He, Yuwei Cong, Dongfang Zhou, Jizhen Li, Zhigang Xie, Xuesi Chen, Xiabin Jing, Yubin Huang*. A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release. Journal of Materials Chemistry B, 2015, 3, 8203-8211.

10. 10. Jing Liu^#, Shasha He^# (co-first author), Yingli Luo, Yue Zhang, Xiaojiao Du, Cheng Xu, Kanyi Pu*, Jun Wang*. Tumor-microenvironment activatable polymer nano-immunomodulator for precision cancer photoimmunotherapy. Advanced Materials, 2022, 34, 2106654.

11. 11. Yan Zhang^#, Shasha He^# (co-first author), Cheng Xu, Yue Jiang, Qingqing Miao, Kanyi Pu*. Activatable polymeric nanoprobe for fluorescence and photoacoustic imaging of tumor-associated neutrophils in cancer immunotherapy. Angewandte Chemie International Edition, 2022, 61, e202203184.

12. 12. Yan Zhang^#, Shasha He^# (co-first author), Wan Chen, Yinghua Liu, Xuefei Zhang, Qingqing Miao, Kanyi Pu*. Activatable polymeric nanoprobe for near-infrared fluorescence and photoacoustic imaging of T lymphocytes. Angewandte Chemie International Edition, 2021, 60, 5921-5927.

13. 13. Qingfei Zhang^#, Shasha He^# (co-first author), Gaizhen Kuang, Sha Liu, Hongtong Lu, Xiaoyuan Li, DongfangZhou, Yubin Huang*. Morphology tunable and acid-sensitive dextran-doxorubicin conjugate assemblies for targeted cancer therapy. Journal of Materials Chemistry B, 2020, 8, 6898-6904.

14. 14. Yan Lyu^#, Shasha He^# (co-first author), Jingchao Li, Yuyan Jiang, He Sun, Yansong Miao, Kanyi Pu*. A photolabile semiconducting polymer nanotransducer for near-infrared regulation of CRISPR/Cas9 gene editing. Angewandte Chemie International Edition, 2019, 58, 18197-18201.

15. 15. Lina Wang, Zejun Liu, Shumei He, Shasha He* (corresponding author) and Yupeng Wang*, Fighting against drug-resistant tumors by the inhibition of gamma-glutamyl transferase with supramolecular platinum prodrug nano-assemblies. Journal of Materials Chemistry B, 2021,9, 4587-4595.

16. 16. Qingfei Zhang, Gaizhen Kuang, Shasha He* (corresponding author), Sha Liu, Hongtong Lu, Xiaoyuan Li, Dongfang Zhou*, Yubin Huang*. Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy. Nano Research, 2021, 14, 601-610.

17. 17. Gaizhen Kuang, Qingfei Zhang, Shasha He* (corresponding author), Ying Liu*. Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy. RSC Advances, 2020, 10, 24624–24630.