E-mail: hpfang@xmu.edu.cn
Address: Tan Kah Kee Innovation Laboratory 5406, Xiamen
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Education and Research Experience:
Bachelor of Polymeric Materials Science and Engineering, Hubei University (2010-2014);
Doctor of Polymeric Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (2014-2019);
Postdoctoral Fellow, Soochow University (2020 -2022);
Associate Professor, Xiamen University (December 2022 - Now).
Principal Research Interests:
Biomedical polymers; Biomaterials; Polymeric nucleic acid/drug carriers; Tumor immunotherapy; Protein/peptide delivery
Selected Recent Publications:
Huapan Fang#, Zhaopei Guo#, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li*, Huayu Tian*, Xuesi Chen. Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo. Nat. Commun. 2021, 12, 6742.
2. Huapan Fang, Zhaopei Guo, Lin Lin, Jie Chen, Pingjie Sun, Jiayan Wu, Caina Xu, Huayu Tian*, Xuesi Chen*. Molecular strings significantly improved the gene transfection efficiency of polycations. J. Am. Chem. Soc. 2018, 140, 11992-12000.
3. Huapan Fang, Linfu Chen, Zheng Deng, Yunxuan Gao, Yang Yang, Qian Chen*, Zhuang Liu*. In situ polymerization of zwitterions on therapeutic proteins to enable their effective oral delivery. ACS Nano 2023, 17, 1128-1143.
4. Huapan Fang, Qian Chen*. An ultrasensitive pH nanodetergent for precise cancer treatment. Matter 2022, 3, 2423-2425.
5. Huapan Fang*, Qian Chen. Applications and challenges of biomaterial mediated mRNA delivery. Explor Target Antitumor Ther. 2022, 3, 428-444.
6. Huapan Fang, Jie Chen, Lin Lin, Feng Liu, Huayu Tian*, Xuesi Chen. A strategy of killing three birds with one stone for cancer therapy through regulating the tumor microenvironment by H2O2-responsive Gene Delivery System. ACS Appl. Mater. Interfaces 2019, 11, 47785-47797.
7. Huapan Fang#, Yuanji Feng#, Jie Chen, Huayu Tian*, Xuesi Chen. Constructing efficient polycationic gene carriers through regulating the physicochemical properties. Mater. Today Chem. 2019, 11, 269-282.
8. Huapan Fang#, Lin Lin#, Jie Chen, Jiayan Wu, Huayu Tian*, Xuesi Chen. Zinc ion coordination significantly improved the transfection efficiency of low molecular weight polyethylenimine. Biomater. Sci., 2019, 7, 1716-1728.
9. Huapan Fang, Huayu Tian*, Xuesi Chen. A pH-sensitive cationic micelle for siRNA delivery. J. Controlled Release 2017, 259, e47.
10. Jie Chen#, Huapan Fang#, Yingying Hu, Jiayan Wu, Sijia Zhang, Yuanji Feng, Lin Lin, Huayu Tian*, Xuesi Chen. Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy. Bioact. Mater. 2022, 7, 167-180.
