Education:

Ph.D. (1996)     Quantum Chemistry, Xiamen University, Xiamen, Fujian Province, China 361005

M.S. (1992)      Nuclear Magnetic Resonance, Xiamen University, Xiamen, Fujian Province, China 361005

B.S. (1986)       Physics, Xiamen University, Xiamen, Fujian Province, China, 361005

Educational and Professional Experiences:

Associate Professor: July. 2009- present

Affiliation: Department of Chemistry, Xiamen University, China.

Research Interests: Protein structure and dynamics, protein-protein interactions, protein-ligand interactions, molecular dynamics simulations, quantum chemistry.

Visiting Scholar: Aug. 2019 - Oct. 2019

Affiliation: The University of Dundee, Dundee DD1 5EH, UK.

Research Interests: Nucleic Acid Structure

Visiting Scholar: Apr. 2018 - June. 2018

Affiliation: The University of North Carolina at Chapel Hill

Research Interests: Cancer structural biology

Visiting Scholar:  Aug. 2015 - Oct. 2015

Affiliation: The Broad Institute of MIT and Harvard, Cambridge, MA, USA

Research Interests: Protein structure and dynamics, protein-ligand interactions

Visiting Scholar: Mar. 2010 - Sept. 2011

Affiliation:  Department of Chemistry, University of Maryland, College Park, Maryland, USA

Research Interests: Protein structure and dynamics, novel NMR techniques

Visiting Scholar: Jan. 2008 - Feb. 2008; July 2004 - Sept. 2004

Affiliation:  Nuclear Magnetic Resonance Laboratory Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China

Research Interests: Protein structure and dynamics, novel NMR techniques

Assistant Professor: Sept. 1996 – July. 2009                                                                

Affiliation: Nuclear Magnetic Resonance Laboratory Department of Chemistry, Xiamen University, China.

Research Interests: Protein structure and dynamics, novel NMR techniques, determination of molecular structure by NMR, NMR applications in chemistry  

Research Interests:

Ÿ Nuclear Magnetic Resonance: NMR experimental techniques, NMR dynamics, NMR instrument maintenance.

Ÿ Statistical thermodynamics：Statistical thermodynamics of equilibrium and non-equilibrium states

Ÿ Quantum Chemistry: Valence Bond Theory, Gaussian 03 Program, Gaussview 3.07

Selected Recent Publications:

1. 1. Fan, Shihui; Zhuang, Jie; Guo, Chenyun; Lin, Donghai; Liao, Xinli*; H-1, C-13, N-15 backbone and side-chain chemical shift assignments of the polyketide cyclase from Mycobacterium tuberc ulosis, Biomolecular NMR Assignments, 15(2): 397-402. (2021)

2. 2. Huang, Lin; Liao, Xinli; Li, Mengxiao; Wang, Jia; Peng, Xuemei; Wilson, Timothy J.; Lille y, David M. J.; Structure and folding of four putative kink turns identified in structured RNA s pecies in a test of structural prediction rules, Nucleic Acids Research, 49(10): 5916-5924. (2021)

3. 3. Xinli Liao; Shaokuan Zheng; Guoxing Lin; Pulsed field gradient signal attenuation of res tricted anomalous diffusions in plate, sphere, and cylinder with wall relaxation, Physical Review E, 101(012128): 1-14 (2020)

4. 4. Biling Huang; Shihui Fan; Yan Liu; Yufen Zhao; Donghai Lin; Xinli Liao*; Solution structure and backbone dynamics for S1 domain of ribosomal protein S1 from Mycobacterium tuberculosis, European Biophysics Journal, 48(6): 491-501.(2019)

5. 5. Y. Fan, Y. Dai, M. Hou, H. Wang, H. Yao, C. Gu, D. Lin*, X. Liao*, Structural basis for ribosome protein S1 interaction with RNA in trans-translation of Mycobacterium tuberculosis. Biochem. Biophys. Resea. Commun. 487 268-273. (2017)

6. 6. J. Fu, B. Huang, D. Lin*, X.Liao* , Chemical shift assignments of Ribosomal protein S1 from Mycobacterium tuberculosis, Biomol NMR Assign 11:133–136.(2017)

7. 7. B. Huang, J. Fu, C. Guo, X.Wu, D. Lin, X.Liao*, ¹ H, ¹⁵N, ¹³C resonance assignments for pyrazinoic acid binding domain of ribosomal protein S1 from Mycobacterium tuberculosis,, Biomol NMR Assign 10:321–324. (2016).

8. 8. G. Lin, S. Zheng, X. Liao, Signal attenuation of PFG restricted anomalous diffusions in plate, sphere, and cylinder, J. Mag. Reson, 272 25–36. (2016)

9. 9. J. Yang, Y. Liu, J. Bi, Q. Cai, X. Liao, W. Li, C. Guo, Q. Zhang, T. Lin, Y. Zhao, H. Wang, J. Liu*, X. Zhang*, D. Lin*. Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide, Molecular Microbiology, DOI: 10.111/mmi.12892 (2014)

10. 10. Fu CP， Peng Y， Liao XL，Guo CY, Lin DH. H-1, C-13, N-15 backbone and side-chain resonance assignments of the human adenylate kinase 1 in apo form. Biomolecular NMR Assignments. Vol 7(2) 155-158 Oct. 2013

11. 11. Liao X, Long D, Li D, Bruschweiler R, Tugarinov V. Probing Side Chain Dynamics in Proteins by the Measurement of Nine Deuterium Relaxation Rates Per Methyl Group. J. Phys. Chem. B 116(1): 606-620 (2012).

12. 12. Liao X, Godoy-Ruiz R • Guo C, Tugarinov V. Simultaneous measurement of ¹H–¹⁵N and Methyl ¹Hm–¹³Cm residual dipolar couplings in large proteins. J Biomol NMR 51:191–198 (2011).

13. 13. Liao X, Tugarinov V, Selective detection of ¹³CHD2 signals from a mixture of ¹³CH3/¹³CH2D/¹³CHD2 methyl isotopomers in proteins, J. Magn. Reson. 209 (1): 101-107 (2011).

14. 14. Liao X, Jung P, Shuai J. Global Noise and Oscillations in Clustered Excitable Media. Physical Review E. 79 (4) 041923,1-6. (2009).

15. 15. Liao X, Chen X and Han D (2008). Interaction of Histidine with Metallic Ions Detected by ¹H-NMR. Journal of Xiamen University (Natural Science). 47: Sup1.55-58.