Education:
Bachelor of Science, College of Chemistry and Chemical Engineering, Nanjing University (2003-2007)
Doctor of Science, Brandeis University, USA (2007-2012)
Postdoctoral Fellow, Department of Chemistry and Chemical Biology, Cornell University, USA (2013-2015)
Associate Professor, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University (2016-)
Principal Research Interests:
Molecular magnetic resonance contrast agent molecular diagnostic reagents molecular probe
Selected Recent Publications:
17. Zhao, Z.#; Sun, C.#; Bao, J.; Yang, L.; Wei, R.; Cheng, J.; Lin, H.; Gao, J. “Surface Manganese Substitution in Magnetite Nanocrystals Enhances T1 Contrast Ability by Increasing Electron Spin Relaxation” J. Mater. Chem. B, 2017, 5, 401-413.
16. Chi, X.#; Yin, Z.#; Jin, J.#; Li, H.#; Zhou, Z.; Zhao, Z.; Zhang, S.; Zhao, W.; Xie, C.; Li, J.; Feng, M.; Lin, H.; Wang, X.*; Gao, J.* “Arsenite-loaded Nanoparticles Inhibit the Invasion and Metastasis of a Hepatocellular Carcinoma: In Vitro and In Vivo Study” Nanotechnology 2017, 28, 445101.
15. Wang, L.#; Lin, H.#; Ma, L.; Sun, C.; Huang, J.; Li, A.; Zhao, T.; Chen, Z.*; Gao, J.* “Geometrical Confinement Directed Albumin-based Nanoprobes as Enhanced T1 Contrast Agents for Tumor Imaging” J. Mater. Chem. B, 2017, 5, 8004-8012.
14. Yang, L.; Ma, L.; Xin, J.; Li, A.; Sun, C.; Wei, R.; Ren, B. W.; Chen, Z.; Lin, H.; Gao, J. “Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability” Chem. Mater. 2017, 29, 3038−3047.
13. Zhu, X.#; Lin, H.#; Wang, L.#; Tang, X.; Ma, L.; Chen, Z.; Gao, J.* “Activatable T1 Relaxivity Recovery Nanoconjugates for Kinetic and Sensitive Analysis of Matrix Metalloprotease 2” ACS Appl. Mater. Interfaces 2017, 9, 21688-21696.
12. Wang, L.#; Lin, H.#; Ma, L.; Jin, J.; Shen, T.; Wei, R.; Wang, X.; Ai, H.; Chen, Z.; Gao, J.* “Albumin-Based Nanoparticles Loaded with Hydrophobic Gadolinium Chelates as T1–T2 Dual-mode Contrast Agents for Accurate Liver Tumor Imaging” Nanoscale 2017, 9, 4516-4523.
11. Sun, C.; Lin, H.; Gao, J. * “Recent Advances in Biological-environment -responsive Smart MRI Contrast Agents” Sci. Sin.: Chim. 2017, 47, 119-132.
10. Long, M. J. C.#; Lin, H.-Y.#; Parvez, S.; Zhao, Y.; Poganik, J. R.; Huang, P.; Aye, Y.* “beta-TrCP1 is a Vacillatory Regulator of Wnt Signaling” Cell Chem. Biol. 2017, 22, 944-957.
09. Parvez, S.#; Long, M. J. C.#; Lin, H.-Y.†; Zhao, Y.†; Haegele, J. A.; Pham, V. N.; Lee, D. K. Aye, Y.* “T-REX On-demand Redox Targeting in Live Cells” Nat. Protoc. 2016, 11, 2328-2356.
08. Lin, H.-Y.; Haegele, J. A.; Disare, M. T.; Lin, Q.; Aye, Y.* “A Generalizable Platform for Interrogating Target- and Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling” J. Am. Chem. Soc. 2015, 137, 6232-6244.
07. Parvez, S. #; Fu, Y. #; Li, J.; Long, M. J. C.; Lin, H.-Y.; Lee, D. K.; Hu, G.S.; Aye, Y.* “Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response” J. Am. Chem. Soc. 2015, 137, 10-13.
06. Fu, Y.; Lin, H.-Y.†; Wisitpitthaya, S.†; Blessing, W. A.; Aye, Y.* “A fluorimetric Readout Reporting the Kinetics of Nucleotide-induced Human Ribonucleotide Reductase Oligomerization” ChemBioChem 2014, 15, 2598-2604.
05. Lin, H.-Y.; Snider, B. B.* “Mn(OAc)3-Based a'-Oxidative Acetoxylation of N-Trifluoroacetyl Vinylogous Amides” Heterocycles 2012, 86, 1391-1400.
04. Lin, H.-Y.; Causey, R.; Garcia, G. E.; Snider, B. B.* “Synthesis of (±)-7-Hydroxylycopodine” J. Org. Chem.2012, 77, 7143-7156.
03. Lin, H.-Y.; Snider, B. B.* “Synthesis of Phidianidines A and B” J. Org. Chem. 2012, 77, 4832-4836.
02. Lin, H.-Y.; Snider, B. B.* “Synthesis of (±)-7-Hydroxylycopodine” Org. Lett. 2011, 13, 1234-1237.
01. Pan, H.; Lin, H.; Shen Q.; Zhu J.-J.* “Cadmium(II) (8-Hydroxyquinoline) Chloride Nanowires: Synthesis, Characterization and Glucose-Sensing Application” Adv. Funct. Mater. 2008, 18, 3692-3698.
