Education:

BS (19**), Zhejiang University
PhD (19**),  Shanghai Institute of Organic Chemistry

Selected Recent Publications: 

1. 1. F.-L. Hong, L.-W. Ye,* Transition Metal-Catalyzed Tandem Reactions of Ynamides for Divergent N-Heterocycle Synthesis, Acc. Chem. Res. 2020, 53, 2003. (invited review paper on the ynamide chemistry)

2. 2. Y.-B. Chen, P.-C. Qian, L.-W. Ye,* Brønsted Acid-Mediated Reactions of Ynamides, Chem. Soc. Rev. 2020, 49, 8897. (invited review paper on the ynamide chemistry)

3. 3. L.-W. Ye,* X.-Q. Zhu, R. L. Sahani, Y. Xu, P.-C. Qian, R.-S. Liu,* Nitrene Transfer and Carbene Transfer in Gold Catalysis, Chem. Rev. 2021, 121, in press. (invited review paper on the metal carbene chemistry)

4. 4. B.-H. Zhu,† Y.-Q. Zhang,† H.-J. Xu, L. Li, G.-C. Deng, P.-C. Qian,* C. Deng,* L.-W. Ye,* Regio- and Stereoselective Synthesis of Diverse 3,4-Dihydro-2-quinolones through Catalytic Hydrative Cyclization of Imine- and Carbonyl-Ynamides with Water, ACS Catal. 2021, 11, 1706.

5. 5. F.-L. Hong, Y.-B. Chen, S.-H. Ye, G.-Y. Zhu, X.-Q. Zhu, X. Lu, R.-S. Liu, L.-W. Ye,* Copper-Catalyzed Asymmetric Reaction of Alkenyl Diynes with Styrenes by Formal [3 + 2] Cycloaddition via Cu-Containing All-Carbon 1,3-Dipoles: Access to Chiral Pyrrole-Fused Bridged [2.2.1] Skeletons,J. Am. Chem. Soc.2020, 142, 7618. (Highlighted by: Synfacts, 2020, 16, 818)

6. 6. Z.-S. Wang, Y.-B. Chen, H.-W. Zhang, Z. Sun, C. Zhu, L.-W. Ye,* Ynamide Smiles Rearrangement Triggered by Visible-Light-Mediated Regioselective Ketyl-Ynamide Coupling: Rapid Access to Functionalized Indoles and Isoquinolines, J. Am. Chem. Soc.2020, 142, 3636. (selected as ESI highly cited papers)

7. 7. X. Liu, Z.-S. Wang, T.-Y. Zhai, C. Luo, Y.-P. Zhang, Y.-B. Chen, C. Deng,* R.-S. Liu, L.-W. Ye,* Copper-Catalyzed Azide-Ynamide Cyclization for Generation of α-Imino Copper Carbenes: Divergent and Enantioselective Access to Polycyclic N-Heterocycles, Angew. Chem. Int. Ed. 2020, 59, 17984.

8. 8. X.-Q. Zhu, Z.-S. Wang, B.-S. Hou, H.-W. Zhang, C. Deng,* L.-W. Ye,*Zinc-Catalyzed Asymmetric Formal [4+3] Annulation of Isoxazoles with Enynol Ethers by 6π Electrocyclization: Stereoselective Access to 2H-Azepines, Angew. Chem. Int. Ed.2020, 59, 1666. (Featured in Chin. J. Org. Chem.2020, 40, 1074)

9. 9. T.-D. Tan, L.-W. Ye,*Chiral γ-lactam synthesis via asymmetric C-H amidation,Nat. Catal. 2019, 2, 182.(News & Views)

10. 10. B. Zhou, Y.-Q. Zhang, K. Zhang, M.-Y. Yang, Y.-B. Chen, Y. Li, Q. Peng,*S.-F. Zhu,* Q.-L. Zhou, L.-W. Ye,* Stereoselective Synthesis of Medium Lactams Enabled by Metal-Free Hydroalkoxylation/Stereospecific [1,3]-Rearrangement,Nat. Commun. 2019, 10, 3234.

11. 11. F.-L. Hong, Z.-S. Wang, D.-D. Wei, T.-Y. Zhai, G.-C. Deng, X. Lu, R.-S. Liu, L.-W. Ye,* Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Diyne Cyclization: Enantioselective and Divergent Synthesis of Chiral Polycyclic Pyrroles, J. Am. Chem. Soc.2019, 141, 16961.(Highlighted by: Synfacts, 2020, 16, 62)

12. 12. Y. Xu, Q. Sun, T.-D. Tan, M.-Y. Yang, P. Yuan, S.-Q. Wu, X. Lu,* X. Hong, L.-W. Ye,*Organocatalytic Enantioselective Conia-Ene-Type Carbocyclization of Ynamide-Cyclohexanones: Regiodivergent Synthesis of Morphans and Normorphans, Angew. Chem. Int. Ed.2019, 58, 16252. (Highlighted by: Synfacts, 2020, 16, 16)

13. 13. T.-D. Tan, X.-Q. Zhu, H.-Z. Bu, G. Deng, Y.-B. Chen, R.-S. Liu, L.-W. Ye,* Copper-Catalyzed Cascade Cyclization of Indolyl Homopropargyl Amides: Stereospecific Construction of Bridged Aza-[n.2.1] Skeletons, Angew. Chem. Int. Ed.2019, 58, 9632. (Featured in Chin. J. Org. Chem. 2019, 39, 2988)

14. 14. L. Li, X.-Q. Zhu, Y.-Q. Zhang, H.-Z. Bu, P. Yuan, J. Chen, J. Su, X. Deng, L.-W. Ye,* Metal-Free Alkene Carbooxygenation Following Tandem Intramolecular Alkoxylation/Claisen Rearrangement: Stereocontrolled Access to Bridged [4.2.1] Lactones,Chem. Sci. 2019, 10, 3123.(selected as the paper of “RSC Editors’ Choice”&ESI highly cited papers)

15. 15. B. Zhou, T.-D. Tan, X.-Q. Zhu, M. Shang, L.-W. Ye,* Reversal of Regioselectivity in Ynamide Chemistry,ACS Catal.2019, 9, 6393. (selected as ESI highly cited papers)

16. 16. C. Shu,† C.-Y. Shi,† Q. Sun, B. Zhou, T.-Y. Li, Q. He, X. Lu,* R.-S. Liu, L.-W. Ye,*Generation of Endocyclic Vinyl Carbene Complexes via Gold-Catalyzed Oxidative Cyclization of Terminal Diynes: Towards Naphthoquinones and Carbazolequinones, ACS Catal.2019, 9, 1019.

17. 17. W.-B. Shen, Q. Sun, L. Li, X. Liu, B. Zhou, J.-Z. Yan, X. Lu,* L.-W. Ye,*  Divergent Synthesis of N-Heterocycles via Controllable Cyclization of Azido-Diynes Catalyzed by Copper and Gold, Nat. Commun. 2017, 8, 1748.

18. 18. B. Zhou, L. Li, X.-Q. Zhu, J.-Z. Yan, Y.-L. Guo, L.-W. Ye*, Yttrium-Catalyzed Tandem Intramolecular Hydroalkoxylation/Claisen Rearrangement: Efficient Synthesis of Medium-Sized Lactams, Angew. Chem. Int. Ed. 2017, 56, 4015. (selected as ESI highly cited papers)

19. 19. W.-B. Shen,† X.-Y. Xiao,† Q. Sun, B. Zhou, X.-Q. Zhu, J.-Z. Yan, X. Lu,* L.-W. Ye*, Highly Site-Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3-Oxazepines and 2,5-Dihydropyridines, Angew. Chem. Int. Ed. 2017, 56, 605. (selected as ESI highly cited papers)

20. 20. L. Li, X.-M. Chen, Z.-S. Wang, B. Zhou, X. Liu, X. Lu,* L.-W. Ye,*Reversal of Regioselectivity in Catalytic Arene-Ynamide Cyclization: Direct Synthesis of Valuable Azepino[4,5-b]indoles and β–Carbolines and DFT Calculations, ACS Catal.2017, 7, 4004.

21. 21. F. Pan,† X.-L. Li,† X.-M. Chen, C. Shu, P.-P. Ruan, C.-H. Shen, X. Lu,* L.-W. Ye,*Catalytic Ynamide Oxidation Strategy for the Preparation of α-Functionalized Amides, ACS Catal.2016, 6, 6055.

22. 22. C. Shu, Y.-H. Wang, B. Zhou, X.-L. Li, Y.-F. Ping, X. Lu,* L.-W. Ye,* Generation of α-Imino Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides, J. Am. Chem. Soc. 2015, 137, 9567. (Highlighted by JACS Homepage; selected as ESI highly cited papers)

23. 23. L. Li,† B. Zhou,† Y.-H. Wang, C. Shu, Y.-F. Pan, X. Lu,* L.-W. Ye,* Zinc-Catalyzed Tandem Alkyne Oxidation/C−H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines, Angew. Chem. Int. Ed. 2015, 54, 8245. (Featured in Chin. J. Org. Chem. 2015, 35, 2019)

24. 24. A.-H. Zhou, Q. He, C. Shu, Y.-F. Yu, S. Liu, T. Zhao, W. Zhang, X. Lu,* L.-W. Ye,* Atom-Economic Generation of Gold Carbenes: Gold-Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles, Chem. Sci. 2015, 6, 1265.(selected as the top 1% of highly cited papers of RSC in 2015-2016& ESI highly cited papers)

25. 25. L. Li,† C. Shu,† B. Zhou, Y.-F. Yu, X.-Y. Xiao, L.-W. Ye,*Generation of Gold Carbenes in Water: Efficient Intermolecular Trapping of the α-Oxo Gold Carbenoids by Indoles and Anilines, Chem. Sci.2014, 5, 4057.